Carpal tunnel syndrome (CTS), a common nerve compression syndrome, is one of the most common causes of hand surgery.1 Recently, CTS has been associated with to heart failure (HF), mainly through an increased rate of detection of transthyretin (ATTR) cardiac amyloidosis among patients with CTS.2 We investigate the association of CTS with HF among a large collective of outpatients. This evidence concerns the gene TTR and cardiac amyloidosis.