Similarly, since patients with postoperative delirium are more likely to have preclinical amyloid or tau pathology (as indicated by low CSF amyloid and high CSF tau levels [147, 148]), the development of postoperative delirium (or EEG patterns associated with it) could be used to identify patients at risk for developing AD for clinical trials and other interventions (such as intensive blood pressure management) that have been shown to reduce MCI and dementia risk [149]. The gene discussed is MAPT; the disease is delirium.