In gene expression analysis (PCR) evaluating the chronology of bone repair, all proteins and enzymes evaluated (RUNX 2; Alkaline phosphatase (ALP); Bone sialoprotein (BSP); and Osteocalcin (OC)), referring to the period osteoblastogenesis and mineral deposition, OVX rats stood out when compared with the others (Sham and SENIL groups), and SENIL was more critical for bone repair, representing that rats that had induced osteoporosis (OVX) were more easily differentiated in cells of osteoblastic lineage. The gene discussed is IBSP; the disease is osteoporosis.