Seventeen articles (total of 8,492 patients) did not report any cases of active TB or LTBI and also pointed to JIA as the most frequent disease.3,5,7–9,13,14,16,17,19,20,26,27,29,31,37,38 Most (10/17) were studies with anti-TNFα medications.3,5,8,14,16,17,20,26,31,37 There were only eight specific papers on TB in children with rheumatic diseases using biologics. The gene discussed is TNF; the disease is juvenile idiopathic arthritis.