Potential mechanisms for the association between T2D and night andshift work include disturbances in the circadian rhythm, that may leadto changes in the hormonal system, such as an increased production ofcortisol and interleukins and a suppression of melatonin secretion atnight, and thereby affect the glucose metabolism and insulin resistance(7, 15, 27). The gene discussed is INS; the disease is type 2 diabetes mellitus.