However, the inhibition of IL‐1β and IL‐18 reduced the efficacy of sorafenib, thereby increasing pyroptosis.[177] The treatment of CRC with gambogic acid (GA) increases the proportion of CD3+ T cells, cytotoxic T lymphocytes, dendritic cells, and effector memory T cells (CD8+, CD44+, and CD62L). This evidence concerns the gene IL18 and colorectal carcinoma.