SIRT6 inhibited the malignant progression of GC by activating the Keap1/NRF2 signaling pathway and upregulating the expression of GPX4.[98] Further, GC cells enhanced their SCD1 expression by secreting exo‐lncFERO into GC stem cells (GCSCs), which inhibited the expression of ferritin by directly interacting with SCD1 mRNA or by recruiting hnRNPA1. The gene discussed is KEAP1; the disease is gastric cancer.