Overall, Tan IIA induced both Nec‐1 inhibition and FLIP regulation‐mediated apoptosis and necroptosis.[154] Inhibition of p66shc expression or promotion of SerpinB3 expression enhanced necroptosis and thus suppressed the malignant progression of HCC.[155] Connexin32 (Cx32) expression was increased in HCC tissues and cell lines, and positively correlated with the expression of necrosis protein biomarkers in xenograft models. This evidence concerns the gene SERPINB3 and hepatocellular carcinoma.