GSDME and colorectal carcinoma: miR‐21‐5p enhanced pyroptosis by targeting TGFB1 and increasing the release of various inflammatory factors such as IL‐1β and IL‐18 and pyroptosis‐related mRNAs and proteins.[195] IRs increased NEAT1 expression, which, in turn, increased GSDME expression by decreasing miR448 levels in CRC cells.