Therefore, DHA induced pyroptosis in ESCC cells through the PKM2/caspase‐8/3/GSDME pathway and inhibited the malignant progression of ESCC.[201] We can imply from these reported results that targeted the key regulators of pyroptosis‐related regulatory network greatly affected the therapeutic effect of various antitumor agents in GI cancers and provided the potential targeted drug research and development directions. Here, GSDME is linked to esophageal squamous cell carcinoma.