In addition, the combination of oxaliplatin and GW4064 promoted SHP expression and inhibited STAT3 signaling.[179] The expression of the deubiquitinating enzyme USP47 was reduced in CRC, and the knockdown of USP47 in CRC cells increased doxorubicin‐induced pyroptosis and apoptosis. This evidence concerns the gene NR0B2 and colorectal carcinoma.