Moreover, metformin treatment reversed the FAM98A‐mediated resistance to 5‐FU in CRC cells.[93] Oxaliplatin treatment reduced cell viability and induced ferroptosis and oxidative stress in CRC cells by inhibiting the NRF2 signaling pathway.[94] Treatment of CRC cells with adipose‐derived exosomes reduced cellular sensitivity to ferritin and increased chemoresistance to oxaliplatin. Here, TSLIG3A is linked to colorectal carcinoma.