Further analysis indicated that these nanoparticles subdued the malignancy of CRC by the regulation of the nuclear factor kappa light‐chain enhancer of activated B cells (NF‐κB) signaling pathway.[101] Ophiopogon B was capable of provoking ferroptosis in GC cells by preventing the GPX4/xCT system.[102] Self‐assembled nanoparticles accelerated the process of lipid peroxidation by increasing the depletion of GSH and stimulating SO2 production. The gene discussed is GPX4; the disease is colorectal carcinoma.