APOC1 and neoplasm: Moreover, miR‐142‐3p downregulated SLC3A2, which promoted the proliferation, migration, and aggression of HCC cells and induced ferroptosis in HBV‐infected M1 macrophages.[78] Glutamine synthase 2 (GLS2) played a significant role in promoting ferroptosis by increasing the conversion of glutamate to α‐ketoglutarate, consequently increasing lipid reactive oxygen species (ROS) production in HCC.[79] Additionally, the expression of Apolipoprotein C1 (APOC1) was found to be substantially higher in tumor‐associated macrophages in HCC tissues than in normal tissues.