In addition, 5‐FU treatment induced GSDME cleavage in GC cells, while knockdown of GSDME shifted 5‐FU‐induced pyroptosis to apoptosis in GC cells.[182] Low concentrations of BIX‐01294 increased the sensitivity of GC cells to chemotherapy and markedly reduced cell viability. This evidence concerns the gene GSDME and gastric cancer.