SNHG7 inhibition decreased SIRT1 expression but increased NLRP3, caspase‐1, and IL‐1β expression levels, thereby enhancing pyroptosis.[191] Treatment of HCC cells with curcumin increased the expression of GSDME N‐terminus as well as other proteins involved in pyroptosis, and enhanced intracellular ROS levels, thereby increasing pyroptosis. This evidence concerns the gene NLRP3 and hepatocellular carcinoma.