Notably, treatment of HCC cells with alpinumisoflavone inhibited cell proliferation, migration, and invasion by enhancing pyroptosis through its induction of NLRP3 inflammasome‐mediated autophagy.[166] Miltirone also decreased the cell viability of HCC cells via proteolytic cleavage of gasdermin E (GSDME) and caspase‐3. Here, GSDME is linked to hepatocellular carcinoma.