SRC and malignant colon neoplasm: Cx32 interacted with Src and enhanced Src‐mediated caspase‐8 phosphorylation and inactivation, thereby inhibiting RIP1‐RIP3 proteolysis.[156] Dimethyl fumarate induced necroptosis in colon cancer cells by depleting GSH, increasing ROS levels, and activating MAPKs.[157] Colon cancer cells treated with 2‐methoxy‐6‐acetyl‐7‐methyljusqualone (MAM) demonstrated the formation of a RIP1/RIP3 complex to promote necroptosis.