S1R inhibition blocked the expression of GPX4, FTH1, and transferrin receptor protein 1, thereby inhibiting ferroptosis and promoting HCC malignant progression.[84] Quiescin sulfhydryl oxidase 1 (QSOX1) acts as a cellular pro‐oxidant by inhibiting NRF2 activation, thereby enhancing the sensitivity of HCC cells to oxidative stress. This evidence concerns the gene GPX4 and hepatocellular carcinoma.