GPX4 and colorectal carcinoma: Treatment of CRC cells with a ferritin inducer, RSL3, contributed to an increase in ROS levels and transferrin expression along with a decrease in GPX4 expression, which, in turn, induced ferroptosis in CRC cells.[108] Overexpression of Serine/arginine‐rich splicing factor 9 (SRSF9) in CRC cells decreased erastin‐induced ferroptosis and increased lipid peroxidation damage.