The Akt regulatory axis modulated the suppressive impact of CBD‐induced aerobic glycolysis on HCC cells.[168] Metformin also induced pyroptosis in HCC cells by upregulating forkhead box O3 (FOXO3) expression, which activated NLRP3 transcription to inhibit cell proliferation and promote apoptosis.[169] Inhibition of NIMA (never in mitosis gene a)‐related kinase 7 (NEK7) inhibited hepatic stellate cell activation in HCC by suppressing NLRP3, caspase‐1, and GSDMD expression, leading to reduced cell viability, migration, invasion, and tumor growth.[170]. This evidence concerns the gene FOXO3 and neoplasm.