Mechanistic tests found an upregulation of the TNF signaling pathway and necrotic cell death pathway‐related protein expression in CCRT‐treated high‐STAT3‐expressing cells, suggesting a direct link between STAT3 and necroptosis.[147] Finally, in GC cells, the combination of the antidepressant fluoxetine with paclitaxel was found to induce apoptosis and necroptosis and block cell cycle progression in the G2/M phase, leading to enhanced antiproliferative effects.[148]. Here, STAT3 is linked to gastric cancer.