This phenomenon could be reversed with the use of demethoxygeldanamycin, a HSP90 inhibitor.[144] In CRC cells, pan‐caspase inhibitors were found to promote 5‐fluorouracil (5‐FU)‐induced necroptosis by increasing the autocrine secretion of TNF‐α. The gene discussed is TNF; the disease is colorectal carcinoma.