This was indicated by the RIPK3‐mediated phosphorylation of pMLKL, elevated cytosolic calcium, and enhanced plasma membrane permeabilization due to pMLKL oligomerization.[140] Radiotherapy has been found to promote necroptosis in CRC cells through the activation of the RIP1/RIP3/MLKL/JNK/IL‐8 pathway, which effectively blocks tumor repopulation. Here, MLKL is linked to colorectal carcinoma.