Moreover, miR‐142‐3p downregulated SLC3A2, which promoted the proliferation, migration, and aggression of HCC cells and induced ferroptosis in HBV‐infected M1 macrophages.[78] Glutamine synthase 2 (GLS2) played a significant role in promoting ferroptosis by increasing the conversion of glutamate to α‐ketoglutarate, consequently increasing lipid reactive oxygen species (ROS) production in HCC.[79] Additionally, the expression of Apolipoprotein C1 (APOC1) was found to be substantially higher in tumor‐associated macrophages in HCC tissues than in normal tissues. This evidence concerns the gene APOC1 and hepatocellular carcinoma.