In addition, the combination of oxaliplatin and GW4064 promoted SHP expression and inhibited STAT3 signaling.[179] The expression of the deubiquitinating enzyme USP47 was reduced in CRC, and the knockdown of USP47 in CRC cells increased doxorubicin‐induced pyroptosis and apoptosis. The gene discussed is STAT3; the disease is colorectal carcinoma.