PCSK1 and hepatocellular carcinoma: Overall, Tan IIA induced both Nec‐1 inhibition and FLIP regulation‐mediated apoptosis and necroptosis.[154] Inhibition of p66shc expression or promotion of SerpinB3 expression enhanced necroptosis and thus suppressed the malignant progression of HCC.[155] Connexin32 (Cx32) expression was increased in HCC tissues and cell lines, and positively correlated with the expression of necrosis protein biomarkers in xenograft models.