In addition, QSOX1 also enhanced sorafenib‐induced ferroptosis by inhibiting NRF2.[85] Secreted protein acidic and rich in cysteine (SPARC) overexpression induced oxidative stress (release of lactate dehydrogenase (LDH) and ROS) leading to ferroptosis in HCC cells, which, in turn, enhanced the cytotoxic influence of sorafenib.[86] Glutathione S‐transferase zeta 1(GSTZ1) enhanced sorafenib‐induced ferroptosis in HCC cells by inhibiting the NRF2/GPX4 axis; notably, its expression was downregulated in sorafenib‐resistant HCC cells.[87]. The gene discussed is SPARC; the disease is hepatocellular carcinoma.