GSDME and hepatocellular carcinoma: The induction of pyroptosis by miltirone is attributed to the increased accumulation of ROS and the inhibition of MEK and ERK1/2 phosphorylation.[167] Furthermore, cannabidiol (CBD) demonstrated a caspase‐3/GSDME‐dependent inhibitory effect on HCC cell growth, inducing pyroptosis by enhancing integrated and mitochondrial stress responses.