MLKL and colorectal carcinoma: FMRP interacted with RIPK1 and increased its expression.[160] In CRC, Phosphofructokinase‐15 (PFK‐15) induced necroptosis by increasing phosphorylation of RIP1, RIP3, and MLKL and further enhancing RIP3 and RIP1/MLKL interactions.[161] Ergothioneine treatment of CRC cells induced the accumulation of ROS, loss of mitochondrial membrane potential, and increased SIRT3 expression.