Induction of apoptosis and necroptosis through modulation of Bcl‐2/caspase family members and RIP1/RIP3 protein expression led to a marked reduction in the growth and viability of Hep3B cells by Fenofibrate.[133] A study revealed that miR‐675 supplemented by the first exon of H19 mRNA, aimed at FADD to enhance cell necroptosis, leading to cell death, thereby obstructing HCC progression.[134] Overexpression of Heparinase (HPSE) in HCC tissues indicated poor prognosis of HCC patients. Here, HPSE is linked to hepatocellular carcinoma.