GSDME and colorectal carcinoma: Specifically, in CRC cell lines, chloroquine (CQ) has been found to upregulate endogenous receptor‐interacting protein kinase 3 (RIPK3), which promoted necroptosis independent of apoptosis inhibitors.[207] Similarly, metformin inhibited cancer cell proliferation by inducing mitochondrial dysfunction and heat‐stimulated cell death via the AMP‐activated protein kinase/sirtuin 1/nuclear factor‐kappa B signal transduction pathway, which activated caspase‐3 and the production of gasdermin E‐pore‐forming domain (GSDME‐PFD).[208] Furthermore, Lu Wang et al.