GSDME and colorectal carcinoma: USP47 binds to TCEA3 and regulates its deubiquitination and intracellular levels, thereby enhancing doxorubicin resistance in CRC cells.[180] STAT3β treatment enhanced cisplatin sensitivity and GSDME‐dependent pyroptosis in ESCC cells; mechanistic tests showed that STAT3β treatment increased ROS levels in cisplatin‐treated cells, thereby activating caspase‐3 and GSDME and thus inducing pyroptosis.