The results showed that the serum concentrations of CRH [P < 0.05, F(3,28) = 44.09], ACTH [P < 0.05, F(3,28) = 53.67], and CORT [P < 0.05, F(3,28) = 70.07] in the IBS rats under chronic atypical stress were significantly increased, whereas the serum contents of CRH, ACTH, and CORT were significantly reduced after EA for 3 days at the rate of 20 min/day. Here, POMC is linked to irritable bowel syndrome.