CGAS and rheumatoid arthritis: To this end, we designed NiH as nanomedicine‐in‐hydrogel composites that allow efficient lymphatic draining and accumulate of cRNPs in LNs, scavenge extracellular/internalized cfDNA, and prolong the release of cGAS inhibitor RU for combinatorial inhibition of proinflammatory responses and enhanced immune tolerance for RA therapy.