Genome-wide profiling analyses revealed that, adding to HLA-B51, myeloid immune cell-related molecules, such as endoplasmic reticulum aminopeptidase-1 (ERAP1), major histocompatibility complex (MHC) class I polypeptide-related sequence-A (MICA), familial Mediterranean (MEFV) gene products, toll-like receptor-4 (TLR-4), c-c motif chemokine receptors CCR1-CCR3, interleukin (IL)-1β, IL-10, interferon (IFN)-γ receptor (IFNGR)-1, IL-23R, and IL-12RB, were risk factors of BD (24–29). This evidence concerns the gene TLR4 and Behcet disease.