Recently, the 5th revision of the WHO classification was published (5), and several alterations were made based on AML, such as the subgroups of KMT2A/MECOM/NUP98 rearrangement and CEBPA mutation, as well as the AML, myelodysplasia-related (MR) subgroup. This evidence concerns the gene MECOM and acute myeloid leukemia.