Recently, the 5th revision of the WHO classification was published (5), and several alterations were made based on AML, such as the subgroups of KMT2A/MECOM/NUP98 rearrangement and CEBPA mutation, as well as the AML, myelodysplasia-related (MR) subgroup. The gene discussed is KMT2A; the disease is acute myeloid leukemia.