Six subgroups, AML with RUNX1::RUNX1T1 (n = 70), AML with CBFB::MYH11 (n = 29), AML with DEK::NUP214 (n = 5), AML with BCR::ABL1 (n = 4), AML with GATA2::MECOM (n = 2), and AML with NPM1 (n = 89), remained unchanged according to the 5th WHO, although the subgroup of AML with GATA2::MECOM was changed to AML with MECOM rearrangement. The gene discussed is CBFB; the disease is acute myeloid leukemia.