We evaluated the activity of this molecule under physiological conditions and in a model of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency, associated with abnormal development of DA neurons (Lloyd et al., 1981; Ernst et al., 1996; Torres and Puig, 2015). This evidence concerns the gene HPRT1 and hyperinsulinemic hypoglycemia, familial, 4.