The screening cascade identified C08, also known as IB-MECA, an A3 adenosine receptor (A3AR) agonist, as a robust promoter of the very early stages of DA neuron genesis, both in physiological conditions and in neurons with HGPRT-deficiency as a model of Lesch–Nyhan disease (LND). This evidence concerns the gene ADORA3 and Lesch-Nyhan syndrome.