The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is known to orchestrate the secretion, maturation, and release of various inflammatory mediators, such as interleukin 18 (IL-18) and IL-1β, that further exacerbate glomerular and tubular damage in DN (Williams et al., 2022). The gene discussed is IL18; the disease is liver dysplastic nodule.