SDHB and metastatic neoplasm: Given the higher risk for metastatic disease in patients with SDHB PVs and reported cases of early-onset of disease during childhood, it is proposed to start screening at age 6–10 for asymptomatic SDHB PV carriers and at age 10–15 for carriers of PVs in SDHA, SDHC, and SDHD genes (Amar et al. 2021).