A final point of interest is that, while not widely expressed in the primary microenvironment, there is evidence that FOXA1 and GATA2 are expressed and functional in the specialised cells of organs such as bone, liver, and lung, to which prostate cancer can metastasise (Lau et al. 2006, Bernardo & Keri 2012, Lambrechts et al. 2018). This evidence concerns the gene GATA2 and Familial prostate cancer.