Comparing PCa AR-cistrome to fibroblast AR-cistrome, the degree of overlap between the two cell types is greatly increased when FOXA1 is silenced in the epithelial prostate cancer cells (Leach et al. 2017a), which suggests a role for FOXA1 in determining phenotypically epithelial specificity of AR signalling. This evidence concerns the gene AR and Familial prostate cancer.