In mouse models and human tissue, GATA2 expression increased with the development of CRPC (Hendriksen et al. 2006, Wang et al. 2009, Vidal et al. 2015), and expression levels are associated with prostate cancer aggression and outcome in patient cohorts (Bohm et al. 2009, He et al. 2014). The gene discussed is GATA2; the disease is Familial prostate cancer.