There have been multiple reports of a specific SNP, CYP3A4 rs680055, and prostate cancer risk after analysis and stratification for factors such as family history of prostate cancer, personal history of benign prostate hyperplasia (BPH), or cigarette smoking (Zeigler-Johnson et al. 2004, Stone et al. 2005, Rebbeck et al. 2008); however, these results were not found by Han et al. in their study of 240 Korean men (Han et al. 2015). This evidence concerns the gene CYP3A4 and Familial prostate cancer.