The absence of this CYP11A1 (ttta)4 shorter allele (and therefore homozygosity for longer CYP11A1 (tttta)6 allele) is associated with hyperandrogenism and increased risk of polycystic ovarian syndrome (Gharani et al. 1997, Diamanti-Kandarakis et al. 2000). This evidence concerns the gene CYP11A1 and hyperandrogenism.