The absence of this CYP11A1 (ttta)4 shorter allele (and therefore homozygosity for longer CYP11A1 (tttta)6 allele) is associated with hyperandrogenism and increased risk of polycystic ovarian syndrome (Gharani et al. 1997, Diamanti-Kandarakis et al. 2000). Here, CYP11A1 is linked to polycystic ovary syndrome.