There is a sex-specific gene landscape, with some genes expressed at higher levels in males compared with females: (1) two growth factors, FGF13and VEGFD involved in angiogenesis, cell growth/proliferation and control of cellular movement/morphology, VEGFD involved also in cell cycle control; (2) cancer-testis antigen (CTAG2) involved in cellular movement, highly expressed also in invasive breast cancer; (3) creatine transporter (SLC6A8) involved in creatine metabolism (Wierinckx et al. 2018). This evidence concerns the gene VEGFD and invasive breast carcinoma.