PROP1 and hypopituitarism: A male patient with hypogonadotropic hypogonadism – КS due to KAL 2 gene mutation (loss of function of fibroblast growth factor receptor 1 – FGF R 1 mutation) and a female patient with congenital hypopituitarism (combined pituitary hormone deficiency - CPHD) due to PROP1 (pituitary homeobox protein prophet of the Pit 1 gene mutation) who both developed in adulthood well-differentiated pituitary adenoma – prolactinoma.