AIP and pituitary gland adenoma: Inactivating AIP mutations lead to pituitary adenoma in 30%, most frequently to somatotropinoma or prolactinoma, often large, invasive and resistant to medical treatment and prone to apoplexy (Vierimaa et al. 2006, Leontiou et al. 2008, Trivellin & Korbonits 2011, Lloyd & Grossman 2014, Pepe et al. 2019).