Moreover, they demonstrated that FLNA knock-down significantly reduced VEGF expression in primary cultured P-NET cells and H727 cells (Vitali et al. 2017), highlighting a key role of FLNA in promoting angiogenesis and bring these results in line with the positive relationship between FLNA and VEGF seen in patients with lung cancer (Uramoto et al. 2010). This evidence concerns the gene VEGFA and lung cancer.