SSAs are recommended for functional and well-differentiated tumors since Pan-NETs are characterized by the expression of SSTRs, particularly SSTR2 (Papotti et al. 2002, Reubi & Schonbrunn 2013), although they achieve control of symptoms and hormone secretion in 50–60% of patients with functioning NET and stabilize tumor mass in 30–50% of cases (Rinke et al. 2009, Öberg 2012, Caplin et al. 2014). Here, SSTR2 is linked to neoplasm.