On the contrary, in GH-secreting pituitary tumor cells, FLNA silencing did not affect SSTR2 levels, and FLNA is required to maintain SSTR2 stability after prolonged agonist stimulation by preventing lysosomal degradation and promoting efficient internalization and recycling to the plasma membrane of endocytosed SSTR2 (Peverelli et al. 2014, Treppiedi et al. 2020). This evidence concerns the gene SSTR2 and pituitary tumor.