Adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumors (PitNETs) are the cause of Cushing’s disease (CD), a rare and potentially fatal systemic condition due to chronic exposure to cortisol, that results in many severe clinical manifestations such as cardiovascular disease, diabetes, hypertension, osteoporosis, infections, and thromboembolic events (Pivonello et al. 2020). This evidence concerns the gene POMC and diabetes mellitus.