Genetic deletion of endothelial HIF-1 reduced Ang II-induced hypertension and kidney injury (Luo et al., 2015), whereas deficiency of endothelial HIF-2 accentuated Ang II-induced albuminuria und podocyte lesions without altering the blood pressure (Wang et al., 2014; Luque et al., 2017). Here, AGT is linked to hypertensive disorder.