The expression levels of genes predominantly regulated by HIF-2, like VEGF-R2, Epo, angiopoietin-2, or CCND1, were markedly upregulated by the presence of renovascular hypertension but not further increased by our intermittent treatment regimen (see Supplementary Table S2), although ICA is generally capable of stabilizing HIF-2 (Schley et al., 2012). Here, CCND1 is linked to renovascular hypertension.