When we administered four injections of the PHD inhibitor ICA in the third week after 2K1C and followed the rats for additional 3 weeks, the development of malignant hypertension, however, was not reduced, and typical features of a malignant course (weight loss, renal onion skin lesions and fibrinoid necroses) remained unchanged by the treatment with ICA. This evidence concerns the gene PDC and malignant hypertension.