Similarly, systemic delivery of P188 for 8 weeks to dystrophic dogs (Golden retriever muscular dystrophy model) markedly reduced myocardial fibrosis, prevented left-ventricular remodeling, and inhibited the increase in cardiac Troponin I (TnI) and brain natriuretic peptide (BNP) in serum (Townsend et al., 2010). The gene discussed is NPPB; the disease is Myocardial fibrosis.