Molecular and genetic studies of ACC have highlighted a number of key molecular predictors of oncogenic progression including TP53, insulin-like growth factor 2 (IGF2), multiple endocrine neoplasia type 1 (MEN1) and β-catenin (CTNNB1) (Giordano et al. 2003, Tissier et al. 2005, Zheng et al. 2016). The gene discussed is IGF2; the disease is adrenal cortex carcinoma.