The most common of these include BRAF V600E mutations in up to 60% of PTCs, RAS mutations in 15% of PTCs and RET/PTC, ALK or NTRK1 chromosomal rearrangements in 12% of papillary carcinomas (Fagin & Wells 2016, Poller & Glaysher 2017). The gene discussed is RET; the disease is papillary carcinoma.