CD40LG and Granuloma: Considering the circulating serum immunoglobulin levels measured at diagnosis, IgM was found to be inversely related to the presence of autoimmunity at diagnosis (R = −0.202) and follow-up (R = −0.218), as well as with granulomas (R = −0.196), GLILD (R = −0.287) or splenomegaly (R = −0.304).