MOG and demyelinating disease of central nervous system: The detection of MOG-Ab became an essential part of the differential diagnosis of CNS demyelinating diseases (5, 10), and it has helped to expand our understanding of the clinical diversity of MOGAD; the clinical syndromes of MOGAD include single/recurrent or bilateral ON, TM, ADEM, brain or brainstem syndrome, and cortical encephalitis (2, 5, 11–13).