Although not detectable in the serum of most patients in our study, BAFF/TNFSF13B has been reported to suppress melanoma growth by potentiating Type-1 monocytes, activated T cells and local production of proinflammatory cytokines while mitigating the suppression mediated by regulatory cell populations, leading to enhanced anti-tumor immunity in melanoma models (16, 17). The gene discussed is TNFSF13B; the disease is melanoma.