Notably, high coordinate expression of the TNFSF13/CXCL10/CXCL13 transcripts in melanomas was correlated with an increased presence of naïve B cells, plasma B cells, CD8+ T cells, and M1 macrophages and decreased levels of M2 macrophages and mast cells as well as a reduced neural network gene signature. This evidence concerns the gene CD8A and melanoma.