Intriguingly, VISTA deficiency did not lead to a severe systemic autoimmune disorder, indicating that other immunoregulatory molecular, such as PD-1, CTLA-4, B7-H3, and B7-H4, might compensate for the VISTA genetic deficiency and mitigated the development of inflammation and autoimmunity induced by genetic loss of VISTA (5). The gene discussed is VSIR; the disease is Autoimmunity.