Furthermore, in order to investigate the prognostic evaluation value of these core TFs, Kaplan–Meier survival analysis was applied, revealing that 14 core TFs (TBX21, MYB, CEBPE, SPIB, GFI1, NFE2L3, ZNF799, TFAP2C, HEY2, NR2F2, IRF4, CREB3, CEBPG, and ESRRA) were related to the overall survival of melanoma (P<0.05) (Figure 14A). This evidence concerns the gene CEBPE and melanoma.