TP53 and melanoma: However, compared to the C4 Melanoma CORO1A, the DEGs of other melanoma cell subtypes were mainly enriched in positive regulation of signal transduction by p53 class mediator, negative regulation of macrophage migration, positive regulation of extrinsic apoptotic signaling pathway, negative regulation of innate immune response, negative regulation of immune system process, negative regulation of immune response, negative regulation of immune effector process, mitotic cell cycle phase transition, regulation of actin filament−based process.