Furthermore, in order to investigate the prognostic evaluation value of these core TFs, Kaplan–Meier survival analysis was applied, revealing that 14 core TFs (TBX21, MYB, CEBPE, SPIB, GFI1, NFE2L3, ZNF799, TFAP2C, HEY2, NR2F2, IRF4, CREB3, CEBPG, and ESRRA) were related to the overall survival of melanoma (P<0.05) (Figure 14A). The gene discussed is SPIB; the disease is melanoma.