The most activated TFs of these melanoma cells subtypes, as determined by the results of the study on cell type-specific regulon activity, included ZNF580 (C0 Melanoma BIRC7), CREB3 (C1 Melanoma CDH19), IRF4 (C2 Melanoma EDNRB), ZNF93 (C3 Melanoma BIRC5), TBX21 (C4 Melanoma CORO1A), ZNF799 (C5 Melanoma MAGEA4), and HEY2 (C6 Melanoma GJB2) (Figure 11). The gene discussed is ZNF580; the disease is melanoma.