Ferroptosis is a form of non-apoptotic cell death that is characterized by iron overload, glutathione (GSH) depletion, glutathione peroxidase 4 (GPX4) inactivation, and an imbalance in lipid and amino acid metabolism (11), which is essential in numerous diseases, including IS and cardiovascular disease (12, 13). Here, GPX4 is linked to cardiovascular disorder.