NPPB and heart failure: While the reduction in NT-proBNP was greater in this larger cohort of sRV failure patients on sacubitril/valsartan, 9 out of 10 patients in the current study had progressive heart failure despite treatment with sacubitril/valsartan in maximally tolerated dose, suggesting that SGLT2i might be of additional value “on top of” sacubitril/valsartan.