Heterozygous mutations in TUBA1A gene, which encodes for one of the major neuronal α-tubulins, has been associated, so far, with severe brain malformations including lissencephaly, cerebellar hypoplasia, agenesis of the corpus callosum, and brain stem anomalies (Keays et al., 2007; Poirier et al., 2007; Kumar et al., 2010; Yokoi et al., 2015; Hebebrand et al., 2019). This evidence concerns the gene TUBA1A and lissencephaly spectrum disorders.