In contrast to the p.R402H mutation, which has been reported to cause lissencephaly (Yokoi et al., 2015) without impairing either TUBA1A protein homeostasis or assembly into microtubules (Figure 5), we showed the p.I384N substitution impairs TUBA1A stability, preventing its incorporation into the lattice (Figures 3, 4). This evidence concerns the gene TUBA1A and lissencephaly spectrum disorders.