As it has previously been evidenced that restoration of the connected mitochondrial phenotype in myotubes from insulin-resistant patients by a mitochondrial anti-fission drug restored insulin-stimulated glucose uptake (Kugler et al., 2021), we evaluated whether restoration of the connected mitochondrial phenotype by TAK242 contributed to insulin-stimulated glucose uptake in myotubes of patients with T2DM. Here, INS is linked to type 2 diabetes mellitus.