With respect to the role of mitochondrial morphology in insulin resistance, it has previously been found that both genetic and pharmacological inhibition of mitochondrial fission restored insulin-stimulated glucose uptake in several models of insulin resistance such as lipotoxicity in C2C12, high-fat diet in mice and myotubes from humans with insulin resistance (Jheng et al., 2012; Kugler et al., 2021). The gene discussed is INS; the disease is Insulin resistance.