Further research has found that YEATS4 is amplified and overexpressed in various types of malignancies [such as astrocytomas, uterine fibroids, liposarcoma, breast cancer, liver cancer, pancreatic cancer, gastric cancer, non-small cell lung cancer, colorectal cancer, ovarian cancer, and other cancers (Fischer et al., 1996; Fischer et al., 1997; Debernardi et al., 2002; Barretina et al., 2010; Park et al., 2011; Schmitt et al., 2012; Pikor et al., 2013; Kim et al., 2015; Kiuchi et al., 2018; Berta et al., 2021)], resulting in malignant progression and poor prognosis of tumors. The gene discussed is YEATS4; the disease is liver cancer.