Li et al. found that YEATS4 expression is upregulated in hepatocellular carcinoma tissues and binds to a specific site in the TCEA1 promoter (Tao et al., 2022), inducing the upregulation of TCEA1 gene expression, which in turn increases DDX3 expression and accelerates the proliferation and migration of hepatocellular carcinoma cells (You et al., 2018). The gene discussed is DDX3X; the disease is hepatocellular carcinoma.