Dysregulation of the human transforming acidic coiled-coil (TACC) protein is associated with the development and progression of breast cancer, where both TACC1 and TACC2 bind to YEATS4 to form complexes that affect the growth and proliferation of breast cancer cells (Lauffart et al., 2002; Lauffart et al., 2003). The gene discussed is TACC2; the disease is breast cancer.