Dymytrii et al. designed a dimer inhibitor based on fragment screening to bind to dimerized YEATS4, block the acetyl-lysine binding channel of the YEATS domain, and impair the recognition and binding of acetylated histone H3 by YEATS4, thereby inhibiting the proliferation of non-small cell lung cancer cells (Listunov et al., 2021). The gene discussed is YEATS4; the disease is non-small cell lung carcinoma.