YEATS4 and non-small cell lung carcinoma: As a member of the YEATS protein family, YEATS4 forms a chromatin-remodeling complex with SRCAP or P400, and the N-terminal of YEATS structural domain specifically recognizes and binds to lysine 27 and lysine 14 of acetylated histone H3, promoting the deposition of the histone variant H2A.Z, loosening the chromatin structure, making it easier to bind to target genes, promoting their transcription and expression, and promoting the progression of NSCLC (Hsu et al., 2018).