YEATS4 acts on-catenin/TCF signaling pathway (Jixiang, Shengchun, Jianguo, Zhengfa, Xin, Xuqing, et al.)and the NOTCH pathway, promoting the expression of downstream genes and resulting in poor prognosis in pancreatic cancer (Han et al., 2022). Here, YEATS4 is linked to familial pancreatic carcinoma.