As mentioned above, in liposarcomas, MDM2 and YEATS4 amplifications appear to be particularly important and can form characteristic giant ring or giant rod marker chromosomes (Persson et al., 2008; Pei et al., 2021), suggesting that YEATS4 can be used as a diagnostic and therapeutic target for liposarcoma (Mashima, Sawada, Nakamura). Here, MDM2 is linked to liposarcoma.