Kaasinen et al. found that the deposition defect of H2A.Z is one of the factors that cause uterine fibroids, and the complex mutation of SRCAP members can cause insufficient deposition of H2A.Z, among these, YEATS4, and ZNHIT1 mutations are the most strongly correlated, resulting in an increased probability of uterine fibroids (Berta et al., 2021). This evidence concerns the gene ZNHIT1 and uterine corpus leiomyoma.