For the low-risk stratification (R=0; AFP<400 ng/ml, albumin>35 g/L and tumor size ≤5cm), there were 556 (83.5%) patients with PS0 and 110 (16.5%) patients with PS1, and there were no differences in baseline characteristics in the two stratifications (all P>0.05, Supplementary Table 1). This evidence concerns the gene ALB and neoplasm.