The PI3K-Akt Pathway is closely related to the malignant behavior of tumor cells, and it manifested its compelling influence on multiple cellular process in different cancers, which are closely related with tumorigenesis, proliferation, growth, apoptosis, invasion, metastasis, epithelial–mesenchymal transition, stem-like phenotype, immune microenvironment and drug resistance of cancer cells (39). This evidence concerns the gene AKT1 and neoplasm.