As shown by others (1–9), the majority of DDX41-MDS/AMLs (22 out of 38) harbored multiple (somatic combined to germline) DDX41 variants (DDX41-m, cases M1-M22); but of note, we also identified 16 MDS/AMLs (cases S14-S29) with a single DDX41 variant (DDX41-s). The gene discussed is DDX41; the disease is myelodysplastic syndrome.