For instance, we have identified several DDX41-s that shared the same single DDX41 variant (eg. p.V303M in S1 and S10, p.M155I in S2 and S19, p.R164W in S20 and S21, p.R159* in S24 and S25) but yet had diverse AML or MPN presentations implying a limited contribution of such solitary DDX41 variants to the biology of these myeloid malignancies. This evidence concerns the gene DDX41 and acute myeloid leukemia.