Furthermore, molecular and cytogenetics tests conducted in parallel to NGS identified other abnormalities (PML-RARA fusion =1, double minute chromosomes with MYC amplification = 1, KMT2A rearrangement =1, ETV6 rearrangement =1) that could explain the origin of AML in 4 additional DDX41-s AMLs (19–21). Here, RARA is linked to acute myeloid leukemia.