An interesting study indicates that binding of Mtb proteins specifically to 16~20 TLR2 LRR domain can trigger NF-κB signaling and TNF-α production in macrophages indicating the importance of such signaling in the regulation of pro-inflammation response which may lead to insulin resistance and type 2 diabetes (Bhat et al., 2012). This evidence concerns the gene TLR2 and Insulin resistance.