It is suggested that MCP-1 probably induces adipocyte dedifferentiation and adds to pathologies associated with hyperinsulinemia, insulin resistance and obesity, including type 2 diabetes (Sartipy and Loskutoff, 2003; Erol, 2008; Panee, 2012). The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.