Among the patients that were healed, we found that core histones such as HIST1H2AJ, HIST1H2AL, HIST1H2BM, HIST1H3B, and HIST1H3G were highly expressed during active infection at 0 weeks (and among the three unhealed patients) but became downregulated at 8 weeks after treatment follow-up, indicating that histone may play a significant role in host immune response to infection resolution. Here, H2BC14 is linked to infection.