The binding of the members of the staphylococcal superantigen-like protein (SSL) family viz. SSL2 and SSL4 to TLR2, SSL10 to CXCR4, and SSL5 to GPCRs, such as P-selectin glycoprotein ligand- 1 (PSGL-1; which normally binds to the P-selectin anchor on endothelial cells) on the leukocyte surface, subsequently blocking neutrophil adhesion and extravasation to the site of infection. Here, SELPLG is linked to infection.