In summary, it was revealed that the LINC00511–hsa-miR-625–5p-SEMA6A axis could regulate tumor autophagy, drug resistance, and apoptosis through phagosome, ABC transporters, and mTOR signaling pathways in SKCM, making it as a promising therapeutic target and a prognostic biomarker. This evidence concerns the gene ABCG2 and neoplasm.