APOE and cancer: Although there was no significant direct effect of APOE-ε4 status on mortality risk, nor each cause of mortality included in the analyses (Table 3), there was a significant chained mediation effect of APOE-ε4 status and causes of mortality related to all other causes than those due to cancers, CVD, respiratory diseases through dementia diagnosis (Indirect effect: HR = 1.03, 95% CI: 1.00, 1.06, p = .030) with a total percent mediated by dementia of 24.0% (Table 3).