Using the risk score, related to degree of proliferation (Ki‐67) and angiogenesis (HE), and IHC to further validate protein expression levels of these genes in our GBM brain tissue samples, we confirmed that ANXA1, COL6A1 and PDPN are not only significantly upregulated in tumor tissues of high‐risk GBM patients, but are closely related to worsened prognosis, indicating their contributions to the pathogenesis of GBM. The gene discussed is COL6A1; the disease is glioblastoma.