In this study, we have constructed a regulatory network based on angiogenesis‐related gene signature and identified a signaling pathway, WWTR1 (TAZ)‐ANXA1, COL6A1, and PDPN‐EMT, which may provide new therapeutic strategies by utilizing the signaling axis in tumor angiogenesis we proposed for GBM patients. Here, COL6A1 is linked to neoplasm.