In the present study, we have constructed a regulatory network based on angiogenesis‐related gene signature and identified a signaling pathway, WWTR1 (TAZ)‐ANXA1, COL6A1 and PDPN‐EMT, which may provide new therapeutic strategies by utilizing the signaling axis in tumor angiogenesis we proposed for GBM patients. This evidence concerns the gene PDPN and glioblastoma.