Eventually, a 12‐PDEARG prognostic signature consisting of MAPK1, ITGA5, NMD3, HEY1, COL6A1, DKK3, SERPINA5, NRP1, PLK2, ANXA1, SLIT2, PDPN was employed to calculate the risk score of GBM samples. The gene discussed is PLK2; the disease is glioblastoma.