Eventually, a 12‐PDEARG prognostic signature consisting of MAPK1, ITGA5, NMD3, HEY1, COL6A1, DKK3, SERPINA5, NRP1, PLK2, ANXA1, SLIT2, PDPN was employed to calculate the risk score of GBM samples. Here, ANXA1 is linked to glioblastoma.