TGF‐β promotes angiogenesis in late stage of tumorigenesis and boosts tumor growth and metastasis through increasing angiogenesis39, 40 and the present study, we hypothesize that COL6A1 worsens the prognosis of GBM patients by promoting angiogenesis through interacting with multiple components of extracellular matrix (ECM). This evidence concerns the gene TGFB1 and neoplasm.