AGER and cancer: On the basis of these findings and in accordance with previous evidence indicating that filopodial protrusions are abundant at the invasive front of cancer cells participating in cellular motility [58, 59], we found that MCF7/RAGE and T47D/RAGE cells display higher migratory (Fig. 3E-F) and invasive (Fig. 3G-H) potential compared to MCF7/wt and T47D/wt cells, respectively.