The established adhesions act as traction sites for locomotion because cells move forward over them, thereafter are disassembled allowing cell detachment and migration [87, 89]. In agreement with these data and other studies showing a role for RAGE in the migratory, invasive, EMT-like phenotype of diverse tumors [30, 77, 90–94], we have established that RAGE overexpression leads to a protrusive cell machinery allied to a motile behavior of BC cells both in vitro and in zebrafish xenograft models. The gene discussed is AGER; the disease is breast cancer.