In contrast, TNF-α signaling via NFкB, and Inflammatory response genes including NFKB1, KLF6, IL6, CCL20, CCL2, CXCL3, SOCS3, and CXCL2, exhibited significantly higher expression in 5ALA + and 5ALA − cells relative to all unsorted tumor regions (Additional file 1: Fig. S2K and Additional file 1: Fig. S2N). The gene discussed is SOCS3; the disease is neoplasm.