Although further evidence of direct binding between these genes is needed, our study demonstrates for the first time that the osteogenic differentiation of PPDLSCs is controlled by the lncRNA00638/miRNA-424-5p/FGFR1 regulatory network under SMS, providing new insights for improving osteogenesis ability and orthodontic efficiency in periodontitis patients. The gene discussed is FGFR1; the disease is periodontitis.