For example, the spliceosome gene SRSF1 mediates tumour cell invasion and maintenance of stem cell properties by controlling Kras splicing in colorectal cancer [19], and SNRPA1 can regulate alternative splicing of PLEC and ERRFI1 to enhance metastatic lung colonization and cancer cell invasion in breast cancer [20]. This evidence concerns the gene SRSF1 and breast carcinoma.