DKC1 and nonpapillary renal cell carcinoma: In the IMmotion 151 ccRCC patients treated with Sunitinib, the angiogenesis score was significantly reduced in the DKC1-high group compared to the low one (high vs low, P = 1.20E-12) (Fig. 6A, left), and the same phenomena were observed in both female (P = 8.79E-07) (Fig. 6A, middle) and male (P = 4.62E-08) patients (Fig. 6A, right).