To identify therapeutically relevant epitopes, we vaccinated rNLS8 mice that develop key features of human ALS/FTD pathology, such as cytoplasmic aggregation and nuclear clearance of TDP-43 as well as progredient motor deficits upon induction of the hTDP-43ΔNLS transgene following doxycycline withdrawal [56]. Here, TARDBP is linked to frontotemporal dementia.