PTGS2 and hepatocellular carcinoma: Also, the downregulation of CRP and COX-2 further gives credence to the anti-HCC potentials of the C. sativa extract because high serum level of CRP has been reported to signify poor prognosis of patients with HCC (Zheng et al. 2013), while COX-2 overexpression has been shown to inhibit tumor cell apoptosis (Wang et al. 2019).