Among them, the proportion of macrophage, activated CD8 T cell, activated CD4 T cell, effector memory CD8 T cell, memory B cell, natural killer cell, natural killer T cell, type 17 T helper cell, Neutrophil, MDSC, plasmacytoid dendritic cell, regulatory T cell, activated dendritic cell increased in AD. The gene discussed is CD4; the disease is Alzheimer disease.