High levels of p16INK4a expression have been suggested as a surrogate marker of HPV and EBV infection in pharyngeal, nasopharyngeal, and oropharynx tumors, whereas in laryngeal tumors are still controversial; therefore, pRb expression may be considered as an additional biomarker, particularly in tumors with infection by HPV and EBV [12, 17–19]. Here, CDKN2A is linked to laryngeal neoplasm.